Mechanism of Tetracycline Resistance in Staphylococcus aureus

The genetics of tetracycline resistance in Staphylococcus aureus.

Eighty-one strains ofStaphylococcus aureus that appeared to be tetracycline resistant on the basis of a preliminary disc-diffusion test were examined fro resistance to tetracycline and to the semi-synthetic tetracycline, minocycline. Minimum inhibitory concentration (m.i.c.) values for both drugs were determined after induction of the strains by growth for 2 h in sub-inhibitory concentrations f...

Development of resistance to novobiocin, tetracycline, and a novobiocin-tetracycline combination in Staphylococcus aureus populations.

The antibiotic sensitivity of the individual organisms of a bacterial population was determined to study the comparative rates of development of resistance of Staphylococcus aureus to novobiocin, tetracycline, and to a combination of these antibiotics. Serial subculture of S. aureus with the combination of novobiocin-tetracycline (N-T 2.5:1; the ratio in serum of patients dosed with Panalba) sh...

Vancomycin Resistance in Staphylococcus aureus Strains

Prevalence of Vancomycin Resistance in Methicillin-Resistant Staphylococcus Aureus

Background & Aims: Staphylococcus aureus is one of the most common pathogens in nosocomial infections. Vancomycin is the most important therapeutic drug of choice for treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA) strains. Therefore, vancomycin-resistant Staphylococcus aureus (VRSA) or vancomycin-intermediate Staphylococcus aureus (VISA) strains are warning...

Phenotypic screening of resistance mechanism in Staphylococcus aureus

Apropos article on antibiotic resistance genes by Duran et al1. I have the following observations. Though the authors have done an excellent job of genotyping resistance mechanism in S. aureus, they failed in phenotypic screening of these isolates. Considering the fact that most laboratories can not afford to perform PCR, phenotypic screening methods remain the backbone for detection of resista...